Detalhe da pesquisa
1.
A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency.
Int J Mol Sci
; 25(5)2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38474031
2.
Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins.
J Proteome Res
; 2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123456
3.
Exploring Charge-Detection Mass Spectrometry on Chromatographic Time Scales.
Anal Chem
; 95(40): 15118-15124, 2023 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37772750
4.
A Native Mass Spectrometry-Based Assay for Rapid Assessment of the Empty:Full Capsid Ratio in Adeno-Associated Virus Gene Therapy Products.
Anal Chem
; 93(38): 12817-12821, 2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34519199
5.
Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells.
Int J Mol Sci
; 22(21)2021 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34768929
6.
Mass spectrometry friendly pH-gradient anion exchange chromatography for the separation of full and empty adeno-associated virus (AAV) capsids.
Anal Methods
; 15(43): 5788-5792, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870407
7.
SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS.
Eur J Pharm Biopharm
; 189: 276-280, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37419424
8.
Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines.
iScience
; 26(2): 105931, 2023 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711246
9.
CAR Gene Delivery by T-cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms.
Adv Sci (Weinh)
; 10(35): e2302992, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37904721
10.
Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs).
J Pharm Biomed Anal
; 207: 114427, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34757284
11.
Native LC-MS for capturing quality attributes of biopharmaceuticals on the intact protein level.
Curr Opin Biotechnol
; 71: 32-40, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34157600
12.
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS.
J Pharm Anal
; 11(6): 726-731, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35028177
13.
Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality.
Front Bioeng Biotechnol
; 9: 569045, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33898396
14.
Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue.
Sci Rep
; 10(1): 7876, 2020 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32398793
15.
In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization.
Front Immunol
; 11: 1824, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33013833
16.
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS / 药物分析学报
Journal of Pharmaceutical Analysis
; (6): 726-731, 2021.
Artigo
em Zh
| WPRIM | ID: wpr-931216